For research use only. Not for therapeutic Use.
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].
COH34 efficiently kills PARP inhibitor-resistant cancer cells[1].
COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models[1].
| Catalog Number | I017830 |
| CAS Number | 906439-72-3 |
| Synonyms | 1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol |
| Molecular Formula | C18H15NOS |
| Purity | ≥95% |
| InChI | InChI=1S/C18H15NOS/c1-13-6-9-15(10-7-13)21-19-12-17-16-5-3-2-4-14(16)8-11-18(17)20/h2-12,20H,1H3/b19-12+ |
| InChIKey | SFUAIBHPGDRCFL-XDHOZWIPSA-N |
| SMILES | CC1=CC=C(C=C1)SN=CC2=C(C=CC3=CC=CC=C32)O |
| Reference | [1]. Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340. |
