For research use only. Not for therapeutic Use.
Col003 (CAT: I019162) is a selective and potent inhibitor of Hsp47, a heat shock protein involved in collagen synthesis and maturation. Col003 competitively binds to the collagen-binding site on Hsp47, preventing the interaction between Hsp47 and collagen molecules. By inhibiting Hsp47, Col003 can disrupt the proper folding and assembly of collagen, which is crucial for maintaining the integrity of connective tissues. This inhibition has potential therapeutic applications in diseases characterized by excessive collagen production or deposition, such as fibrosis.
| Catalog Number | I019162 |
| CAS Number | 328565-16-8 |
| Molecular Formula | C₁₄H₁₁NO₄ |
| Purity | ≥95% |
| Reference | [1]. Ito S, et al. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. J Biol Chem. 2017 Dec 8;292(49):20076-20085. |
