Colestipol HCl

For research use only. Not for therapeutic Use.

  • CAT Number: I025071
  • CAS Number: 37296-80-3
  • Molecular Formula: C8H24ClN5
  • Molecular Weight: 225.77
  • Purity: 98%
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Colestipol HCl (Cat. No: I025071) is a standard substance, which is often used as a reference substance in analytical chemistry and is mainly used to treat hypercholesterolemia in clinical practice.


Catalog Number I025071
CAS Number 37296-80-3
Synonyms

Colestipol HCl; U26597A; U 26597A; U-26597A

Molecular Formula C8H24ClN5
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name N1-(2-aminoethyl)-N2-(2-((2-aminoethyl)amino)ethyl)ethane-1,2-diamine hydrochloride
InChI InChI=1S/C8H23N5.ClH/c9-1-3-11-5-7-13-8-6-12-4-2-10;/h11-13H,1-10H2;1H
InChIKey GACQNVJDWUAPFY-UHFFFAOYSA-N
SMILES NCCNCCNCCNCCN.Cl
Reference

1: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Colestipol. 2017 Sep 28. PMID: 31643751.
2: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Colestipol. 2018 Oct 31. PMID: 30000452.
3: Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS. Colestipol: a review of its pharmacological properties and therapeutic efficacy in patients with hypercholesterolaemia. Drugs. 1980 Mar;19(3):161-80. doi: 10.2165/00003495-198019030-00001. PMID: 6988203.
4: Lipid-lowering drugs. Med Lett Drugs Ther. 2019 Feb 11;61(1565):17-24. PMID: 30845106.
5: Nekl KE, Aron DC. Hydrocortisone-colestipol interaction. Ann Pharmacother. 1993 Jul-Aug;27(7-8):980-1. doi: 10.1177/106002809302700734. PMID: 8364291.
6: Comparison table: Some lipid-lowering drugs. Med Lett Drugs Ther. 2019 Feb 11;61(1565):e24-e30. PMID: 30845107.
7: Sirmans SM, Beck JK, Banh HL, Freeman DA. Colestipol-induced hepatotoxicity. Pharmacotherapy. 2001 Apr;21(4):513-6. doi: 10.1592/phco.21.5.513.34501. PMID: 11310528.
8: Glueck CJ. Colestipol and probucol: treatment of primary and familial hypercholesterolemia and amelioration of atherosclerosis. Ann Intern Med. 1982 Apr;96(4):475-82. doi: 10.7326/0003-4819-96-4-475. PMID: 7039445.
9: Camilleri M, Vijayvargiya P. The Role of Bile Acids in Chronic Diarrhea. Am J Gastroenterol. 2020 Oct;115(10):1596-1603. doi: 10.14309/ajg.0000000000000696. PMID: 32558690; PMCID: PMC7541465.
10: Robertson D, Dixon C, Aungst A, McCoy B, Moreo N, Casady L, Maldonado J. Tolerability and efficacy of colestipol hydrochloride for accelerated elimination of teriflunomide. Expert Rev Clin Pharmacol. 2017 Dec;10(12):1403-1407. doi: 10.1080/17512433.2017.1395280. Epub 2017 Nov 2. PMID: 29064296.

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