For research use only. Not for therapeutic Use.
Polymyxin E1 sulfate or colistin A is one of the two major components of polymyxin E (colistin). Polymyxin E1 and E2 are structurally similar and differ only by a fatty acid group at the N-terminus. Polymyxin E1 contains 6-methyloctanoic acid and polymyxin E2 (colistin B) contains 6-methylheptanoic acid. Together, polymyxin E1 and E2 comprise approximately 85% of polymyxin E; however, 13 different polymyxin E components have been indentified.
Catalog Number | R021210 |
CAS Number | 7722-44-3 |
Synonyms | Polymixin E1; 1,4,7,10,13,16,19-Heptaazacyclotricosane Cyclic peptide deriv.; Colistin IV; N2-(6-Methyl-1-oxooctyl)-L-2,4-diaminobutanoyl-L-threonyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-D-leucyl-L-leucyl-L-2,4-diaminobuta |
Molecular Formula | C53H100N16O13 xH2SO4 (lot specific) |
Purity | ≥95% |
Storage | -80°C |
Reference | <p>Falagas, M. E. /Colistin: The Revival of Polymyxins for the Management of Multidrug-resistant Gram-negative Bacterial Infections./ <em>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</em> 40.9 (2005): 1333-341. <em>www.ncbi.gov</em>. Web. 10 Sept. 2012.</p>Bergen, Philip J. et. al. /Colistin Methanesulfonate Is an Inactive Prodrug of Colistin against Pseudomonas Aeruginosa./ Antimicrobial Agents and Chemotherapy 50.6 (2006): 1953-958. Ncbi.gov. Web. 5 Oct. 2012.<p>Leifert C., Ritchie J.Y. and Waites W.M., Contaminants of plant-tissue and cell cultures. World Journal of Microbiology and Biotechnology, Vol. 7, pp. 452-469, 1991.</p><p>MJ Mueller, W Brodschelm. /Signaling in the elicitation process is mediated through theoctadecanoid pathway leading to jasmonic acid/. Proc. Natl. Acad. Sci. USAVol. 90, pp. 7490-7494, August 1993.</p><p>Li, Jian, and Roger L. Nation. /Comment On: Pharmacokinetics of Inhaled Colistin in Patients with Cystic Fibrosis./ Journal of Antimicrobial Chemotherapy (2006): 222-23. Oxfordjournals.org. Web. 19 June 2013.</p><p>Decolin, Dominique, and Pierre Leroy. /Hyphenated Liquid Chromatographic Method for the Determination of Colistin Residues in Bovine Tissues./ Oxfordjournals.org. N.p., n.d. Web. 19 June 2013.</p></span></p> |