Collagen proline hydroxylase inhibitor-1

• CAT Number: I002720
• CAS Number: 223663-32-9
• Molecular Formula: C24H21N5O4
• Molecular Weight: 443.45
• Purity: ≥95%
• Synonyms: 8-(4-benzylpiperazine-1-carbonyl)-3-nitro-1,10-phenanthrolin-4(1H)-one
• Target: MMP
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 8-(4-benzylpiperazine-1-carbonyl)-3-nitro-1H-1,10-phenanthrolin-4-one
• InChI: InChI=1S/C24H21N5O4/c30-23-19-7-6-17-12-18(13-25-21(17)22(19)26-14-20(23)29(32)33)24(31)28-10-8-27(9-11-28)15-16-4-2-1-3-5-16/h1-7,12-14H,8-11,15H2,(H,26,30)
• InChIKey: HPDVDDAVQSIBPH-UHFFFAOYSA-N
• SMILES: C1CN(CCN1CC2=CC=CC=C2)C(=O)C3=CN=C4C(=C3)C=CC5=C4NC=C(C5=O)[N+](=O)[O-]

Collagen Proline Hydroxylase Inhibitor-1 (CPI-1)(CAT: I002720) is a potent and selective inhibitor of prolyl 4-hydroxylase, an enzyme critical for collagen synthesis and stabilization. By inhibiting prolyl 4-hydroxylation, CPI-1 disrupts collagen triple-helix formation, making it a valuable tool in fibrosis research, where excessive collagen deposition contributes to organ dysfunction. It also aids studies in oncology, where tumor-associated fibrosis impacts treatment efficacy, and in metabolic diseases, such as diabetic complications involving extracellular matrix remodeling. CPI-1’s targeted mechanism offers insights into therapeutic strategies to regulate pathological collagen production and associated tissue remodeling in various disease contexts.