Combretastatin A4

• CAT Number: I000606
• CAS Number: 117048-59-6
• Molecular Formula: C₁₈H₂₀O₅
• Molecular Weight: 316.35
• Purity: ≥95%
• Synonyms: (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)phenol
• Target: Antiangiogenics
• Solubility: DMSO: 63 mg/mL; Ethanol: 34 mg/mL (warming); Water: ≤ 1 mg/mL
• Storage: Desiccate at -20C
• IUPAC Name: 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
• InChI: InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
• InChIKey: HVXBOLULGPECHP-WAYWQWQTSA-N
• SMILES: COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)O

Combretastatin A4（Cat No.:I000606）is a potent microtubule-targeting agent derived from the African bush willow Combretum caffrum. It disrupts the polymerization of tubulin, leading to the collapse of tumor blood vessels and inhibiting cancer cell growth. Due to its selective cytotoxicity against rapidly dividing cells, it is being explored for its potential in anti-cancer therapies. Combretastatin A4’s vascular-disrupting properties make it an attractive candidate for combination with other treatments to enhance tumor suppression and improve clinical outcomes in various cancers.

Reference

[1]. Tochinai R, et al. Combretastatin A4 disodium phosphate-induced myocardial injury. J Toxicol Pathol. 2016 Jul;29(3):163-71.

[2]. Signoretto E, et al. Stimulation of Eryptosis by Combretastatin A4 Phosphate Disodium (CA4P). Cell Physiol Biochem. 2016;38(3):969-81

[3]. Zhu J, et al. Co-Encapsulation of Combretastatin-A4 Phosphate and Doxorubicin in Polymersomes for Synergistic Therapy of Nasopharyngeal Epidermal Carcinoma. J Biomed Nanotechnol. 2015 Jun;11(6):997-1006.

[4]. Yao N, et al. Combretastatin A4 phosphate treatment induces vasculogenic mimicry formation of W256 breast carcinoma tumor in vitro and in vivo. Tumour Biol. 2015 Nov;36(11):8499-510.