Compound 11

• CAT Number: I020970
• CAS Number: 842964-18-5
• Molecular Formula: C10H12N4O2
• Molecular Weight: 220.23
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: NC1=CC=C(N2CCOCC2)C3=NON=C13

Compound 11, a non-toxic and selective δ-secretase inhibitor (IC50=0.7 μM, in fluorescence-based assay) that interacts with both the active site and allosteric site of δ-secretase in Co-crystal structure analysis. The IC50 value of the compound 11 towards δ-secretase in Pala cells is 0.8 μM.

Reference

[1] Zhang Z, et al. Nat Commun. 2017 Mar 27;8:14740.
[2] Wang J, et al. Transl Neurodegener. 2021 Mar 31;10(1):12.