Compound C108

• CAT Number: R067701
• CAS Number: 15533-09-2
• Molecular Formula: C15H14N2O3
• Molecular Weight: 270.28
• Purity: ≥95%
• Synonyms: 2-hydroxy-N-[(E)-1-(2-hydroxyphenyl)ethylideneamino]benzamide
• InChI: InChI=1S/C15H14N2O3/c1-10(11-6-2-4-8-13(11)18)16-17-15(20)12-7-3-5-9-14(12)19/h2-9,18-19H,1H3,(H,17,20)/b16-10+
• InChIKey: LQGMBUGEAAGJKW-MHWRWJLKSA-N
• SMILES: CC(=NNC(=O)C1=CC=CC=C1O)C2=CC=CC=C2O

Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis[1][2].
Compound C108 (1 μM; 24 h) shows anti-tumor activity against BT474 cells[1].
Compound C108 (4 μM; 24 h) significantly decreases the protein expression of G3BP2 in G3BP2 overexpressing KYSE410 cells and LINC01554 transfected KYSE30 cells[2].
Compound C108 (4 μM; 24 h) attenuates ESCC cell metastasis, migration and invasion in KYSE410, KYSE30 and KYSE150 cells[2].
Compound C108 (1 μM; 24 h) targets and decreases tumor initiating cells (TICs), while injected BT-474 cells treated with Compound C108 into the mammary fat pad of female nonobese diabetic/severe combined immune deficiency (NOD-SCID) mice in a limiting-dilution xenograft assay[1].

Reference

[1]. Gupta N, et al. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1033-1038.
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[2]. Zheng Y, et al. G3BP2 regulated by the lncRNA LINC01554 facilitates esophageal squamous cell carcinoma metastasis through stabilizing HDGF transcript. Oncogene. 2022 Jan;41(4):515-526.
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