Conduritol B Epoxide

• CAT Number: I004297
• CAS Number: 6090-95-5
• Molecular Formula: C₆H₁₀O₅
• Molecular Weight: 162.14
• Purity: ≥95%
• Synonyms: 1,2-anhydro-myo-inositol
• Target: Glucosidase
• Solubility: H2O: ≥ 30 mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H/t1-,2-,3+,4+,5-,6+/m0/s1
• InChIKey: ZHMWOVGZCINIHW-FTYOSCRSSA-N
• SMILES: C1(C(C(C2C(C1O)O2)O)O)O

Conduritol B epoxide (CAT: I004297) is a potent and irreversible inhibitor of glycosidases, specifically targeting α-glucosidases. It is a synthetic derivative of conduritol, a naturally occurring cyclohexane polyol. Conduritol B epoxide covalently modifies the active site of α-glucosidases, leading to their inhibition. This compound has been used in various biochemical and pharmacological studies to investigate the role of glycosidases in biological processes and to develop therapeutic strategies for diseases associated with abnormal carbohydrate metabolism.

Reference

[1]. Liou B, et al. Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. Hum Mol Genet. 2016 Sep 20. pii: ddw322. [Epub ahead of print]
[2]. YH Xu, et al. Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models. Mol Genet Metab. Author manuscript; available in PMC 2012 Apr 1.