Conessine

• CAT Number: R059740
• CAS Number: 546-06-5
• Molecular Formula: C24H40N2
• Molecular Weight: 356.59
• Purity: ≥95%
• Synonyms: N,18-Dihydrotrimethylconkurchine; (+)-Conessine; Conessin; NSC 119994; Neriine; N’,18-Dihydro-N,N,N’-trimethylconkurchine; Roquessine; Wrightine; (3β)-N,N-Dimethylcon-5-enin-3-amine; 3β-(Dimethylamino)con-5-enine
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at RT
• IUPAC Name: (1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethyl-7-azapentacyclo[10.8.0.02,9.05,9.013,18]icos-18-en-16-amine
• InChI: InChI=1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1
• InChIKey: GPLGAQQQNWMVMM-MYAJQUOBSA-N
• SMILES: C[C@H]1[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3CC=C5[C@@]4(CC[C@@H](C5)N(C)C)C)CN1C

Conessine（Cat No.:R059740）is a steroidal alkaloid derived from the bark of plants like Holarrhena antidysenterica. It has been traditionally used in herbal medicine for its antimicrobial, anti-inflammatory, and anti-dysenteric properties. Conessine is known to act as a potent histamine H3 receptor antagonist, making it valuable in neurological research, particularly in studying conditions related to cognition, sleep, and appetite regulation. Its broad biological activity also includes antifungal and antibacterial effects, making it a compound of interest for developing treatments for infections and neurodegenerative disorders.