For research use only. Not for therapeutic Use.
Isolated from Streptomyces conglobatus, conglobatin has a unusual dimeric macrolide dilactone structure with pendant oxazole
groups. Conglobatin exhibits an IC50 of 0.63 μg/ml in a NFAT-dependant transcription assay. No toxicity was observed at
doses up to 1000 mg/kg when administered to mice either orally or interperitoneally.
| Catalog Number | R001875 |
| CAS Number | 72263-05-9 |
| Synonyms | (3E,5R,11E)-3,5,7S,11,13R,15S-hexamethyl-8S,16S-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione |
| Molecular Formula | C28H38N2O6 |
| Purity | 98% |
| Target | Metabolic Enzyme/Protease |
| Appearance | Powder |
| Storage | 2-8°C |
| Analysis method | HPLC |
| IUPAC Name | (3Z,5R,7S,8S,11Z,13R,15S,16S)-3,5,7,11,13,15-hexamethyl-8,16-bis(1,3-oxazol-5-ylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione |
| InChI | InChI=1S/C28H38N2O6/c1-17-7-19(3)25(11-23-13-29-15-33-23)35-28(32)22(6)10-18(2)8-20(4)26(12-24-14-30-16-34-24)36-27(31)21(5)9-17/h9-10,13-20,25-26H,7-8,11-12H2,1-6H3/b21-9-,22-10-/t17-,18-,19+,20+,25+,26+/m1/s1 |
| InChIKey | LAJRJVDLKYGLOO-NLISZJEWSA-N |
| SMILES | CC1CC(C(OC(=O)C(=CC(CC(C(OC(=O)C(=C1)C)CC2=CN=CO2)C)C)C)CC3=CN=CO3)C |
| Reference | Westley, John W., and Ralph H. Evans. /The Journal of Antibiotics./ Conglobatin, A Novel Macrolide Dilactone from Streptomyces Conglobatus ATCC 31005 32.0 (1979): 874-77. Ncbi.gov. Web. 25 Feb. 2013. |
