For research use only. Not for therapeutic Use.
Corrector and potentiator (Co-Po) for ∆F508-cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel function in cystic fibrosis, with low micromolar EC50
| Catalog Number | I047563 |
| CAS Number | 606101-83-1 |
| Molecular Formula | C22H22N4O2 |
| Purity | ≥95% |
| IUPAC Name | N-[2-[(3-cyano-5,7-dimethylquinolin-2-yl)amino]ethyl]-3-methoxybenzamide |
| InChI | InChI=1S/C22H22N4O2/c1-14-9-15(2)19-12-17(13-23)21(26-20(19)10-14)24-7-8-25-22(27)16-5-4-6-18(11-16)28-3/h4-6,9-12H,7-8H2,1-3H3,(H,24,26)(H,25,27) |
| SMILES | CC1=CC(=C2C=C(C(=NC2=C1)NCCNC(=O)C3=CC(=CC=C3)OC)C#N)C |
| Reference | PW Phuan et al. Cyanoquinolines with Independent Corrector and Potentiator Activities Restore ∆F508-CFTR Chloride Channel Function in Cystic Fibrosis. Mol. Pharmacol. 2011, 80(4), 683-693.
AS Verkman et al. CFTR chloride channel drug discovery–inhibitors as antidiarrheals and activators for therapy of cystic fibrosis. Curr. Pharm. Des. 2006; 12(18), 2235-2247. |
