Coptisine

• CAT Number: I003278
• CAS Number: 3486-66-6
• Molecular Formula: C19H14NO4+
• Molecular Weight: 320.32
• Purity: ≥95%
• Target: Indoleamine 2,3-Dioxygenase (IDO)
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• IC50: Ki value of coptisine was 3.3 microM

Coptisine (Cat.No:I003278) is a naturally occurring alkaloid found in the roots of various Coptis species, including Coptis chinensis. Known for its potent pharmacological properties, Coptisine has shown potential in treating cardiovascular diseases, diabetes, and inflammation. Its diverse therapeutic applications make it a promising compound in drug discovery and development.

Reference

[1]. W.-J. Kong, et al. Investigation of the anti-fungal activity of coptisine on Candida albicans growth by microcalorimetry combined with principal component analysis. Journal of Applied Microbiology
Volume 107, Issue 4, pages 1072–1080, October 2009

[2]. JS Ro, et al. Inhibition of type A monoamine oxidase by coptisine in mouse brain. Life sciences, 2001, 70 (6): 639-45

[3]. Tanabe H, et al. Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells. Biochemical Pharmacology, 2005, 70 (8): 1176-1184

[4]. Friedemann T, et al. Neuroprotective Activity of Coptisine from Coptis chinensis (Franch). Evid Based Complement Alternat Med. 2015;2015:827308.

[5]. Chen B, et al. [Regulatory effect of coptisine on key genes involved in cholesterol metabolism]. Zhongguo Zhong Yao Za Zhi. 2015 Apr;40(8):1548-53.

[6]. Wu J, et al. Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. Eur J Pharmacol. 2016 Mar 24. pii: S0014-2999(16)30167-4.