COQ7-IN-1

For research use only. Not for therapeutic Use.

  • CAT Number: I045314
  • CAS Number: 2579696-72-1
  • Molecular Formula: C14H10ClN3O
  • Molecular Weight: 271.70
  • Purity: ≥95%
Inquiry Now

COQ7-IN-1, a highly potent inhibitor of human coenzyme Q (COQ7), interferes with ubiquinone (UQ) synthesis. COQ7-IN-1 does not disturb physiological cell growth of human normal culture cells. COQ7-IN-1 can be used for the research of the balance between UQ supplementation pathways: de novo UQ synthesis and extracellular UQ uptake[1].
COQ7-IN-1 (Compound 8; 0-30 μM; for 4 days) inhibits WI-38 cells growth with a GI50 of 19.0 μM. COQ7-IN-1 weakly inhibits C3A cells growth with GI50 of 9.0±1.1 μM. COQ7-IN-1 does not limit C3A cell survival through inhibiting aerobic respiration or increasing oxidative stress[1].
COQ7 converts demethoxy-UQ (DMQ) to demethyl-UQ (DMeQ), and then converted to UQ by COQ3. Cells under COQ7 deficiency are unable to produce UQ, and consequently accumulate DMQ. DMQ10 and UQ10 contents in each culture well are 13.2 and 12.2 ng/well for COQ7-IN-1 (10 μM; for 2 days) cultured with HeLa cells. DMQ10 content of COQ7-IN-1 in HeLa cells is 52.0%[1].


Catalog Number I045314
CAS Number 2579696-72-1
Synonyms

2-(5-chloropyridin-2-yl)-5-phenyl-1H-pyrazol-3-one

Molecular Formula C14H10ClN3O
Purity ≥95%
InChI InChI=1S/C14H10ClN3O/c15-11-6-7-13(16-9-11)18-14(19)8-12(17-18)10-4-2-1-3-5-10/h1-9,17H
InChIKey IRQULQWSSURBFT-UHFFFAOYSA-N
SMILES C1=CC=C(C=C1)C2=CC(=O)N(N2)C3=NC=C(C=C3)Cl
Reference

[1]. Keiko Tsuganezawa, et al. Identification of small molecule inhibitors of human COQ7. Bioorg Med Chem. 2020 Jan 1;28(1):115182.
 [Content Brief]

Request a Quote