COQ7-IN-2

• CAT Number: I044629
• CAS Number: 2579696-76-5
• Molecular Formula: C15H13N3O
• Molecular Weight: 251.28
• Purity: ≥95%
• Synonyms: 2-(5-methylpyridin-2-yl)-5-phenyl-1H-pyrazol-3-one
• InChI: InChI=1S/C15H13N3O/c1-11-7-8-14(16-10-11)18-15(19)9-13(17-18)12-5-3-2-4-6-12/h2-10,17H,1H3
• InChIKey: SKJOGGJAXXEJKE-UHFFFAOYSA-N
• SMILES: CC1=CN=C(C=C1)N2C(=O)C=C(N2)C3=CC=CC=C3

COQ7-IN-2 (compound 12) is an inhibitor of COQ7, witn IC50 values of 7.3 μM and 15.4 μM for DMQ10 and UQ10 accumulation, respectively[1].
COQ7-IN-2 (compound 12) has less growth inhibition against human normal culture cells[1].
The substantial DMQ10 accumulation occurred in both PANC-1 cells (8.7% by COQ7-IN-2 (compound 12)) and PC3 cells (14.0% by COQ7-IN-2 (compound 12))[1].

Reference

[1]. Keiko Tsuganezawa, et al. Identification of small molecule inhibitors of human COQ7. Bioorg Med Chem. 2020 Jan 1;28(1):115182.
 [Content Brief]