(-)-Corey Lactone Diol

• CAT Number: R016542
• CAS Number: 32233-40-2
• Molecular Formula: C8H12O4
• Molecular Weight: 172.18
• Purity: ≥95%
• Synonyms: (3aR,4S,5R,6aS)Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one; [3aR-(3aα,4α,5β,6aα)]Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one
• Target: Disease Research Fields
• Storage: Room temperature
• IUPAC Name: (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
• InChI: InChI=1S/C8H12O4/c9-3-5-4-1-8(11)12-7(4)2-6(5)10/h4-7,9-10H,1-3H2/t4-,5-,6-,7+/m1/s1
• InChIKey: VYTZWRCSPHQSFX-GBNDHIKLSA-N
• SMILES: C1C(C(C2C1OC(=O)C2)CO)O

Corey aldehyde is a versatile, hydroxy-<wbr></wbr>lactone intermediate for the synthesis of prostaglandins and prostaglandin analogs. Prostaglandin derivatives with modifications in the α chain, the ω chain, or both, are readily accessible from this general intermediate. (−)-<wbr></wbr>Corey lactone diol is simply the reduced version of Corey aldehyde, with alcohol groups at both C-<wbr></wbr>11 and C-<wbr></wbr>13. This allows the introduction of ω chain constituents via alternate chemistries, such as nucleophilic displacements.