CORM-3

For research use only. Not for therapeutic Use.

  • CAT Number: I000012
  • CAS Number: 475473-26-8
  • Molecular Formula: C5H4ClNO5Ru
  • Molecular Weight: 294.61
  • Purity: ≥95%
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CORM-3 (CAT: I000012) is a carbon monoxide-releasing molecule that serves as a donor of controlled amounts of carbon monoxide (CO) in biological systems. CORM-3 has demonstrated various pharmacological activities, including anti-inflammatory, vasodilatory, and cytoprotective effects. It has been studied for its potential therapeutic applications in conditions such as ischemia-reperfusion injury, organ transplantation, sepsis, and inflammatory diseases. CORM-3 functions by delivering CO, which acts as a signaling molecule, regulating cellular processes and exerting protective effects. Although the precise molecular targets and mechanisms of action of CORM-3 are still being elucidated, it holds promise as a therapeutic agent with potential clinical applications in diverse pathological conditions.


Catalog Number I000012
CAS Number 475473-26-8
Synonyms

Carbon monoxide releasing molecule 3; Tricarbonylchloro(glycinato)ruthenium (II)

Molecular Formula C5H4ClNO5Ru
Purity ≥95%
Target Immunology/Inflammation
Solubility Soluble in DMSO > 10 mM
Storage Store at -20°C
SMILES O=C1[O-][Ru+2]([Cl-])([C]=O)([C]=O)([C]=O)[NH2]C1
Reference

1: Yan BZ, Yang BS, Li H, Zhang YF, Pei FH, Zhu AC, Wang XR, Liu BR. The
therapeutic effect of CORM-3 on acute liver failure induced by
lipopolysaccharide/D-galactosamine in mice. Hepatobiliary Pancreat Dis Int. 2016
Feb;15(1):73-80. PubMed PMID: 26818546.<br />
2: Wilson JL, McLean S, Begg R, Sanguinetti G, Poole RK. Analysis of transcript
changes in a heme-deficient mutant of Escherichia coli in response to CORM-3
[Ru(CO)(3)Cl(glycinate)]. Genom Data. 2015 Jun 13;5:231-234. eCollection 2015
Sep. PubMed PMID: 26322270; PubMed Central PMCID: PMC4543538.<br />
3: Wilson JL, Wareham LK, McLean S, Begg R, Greaves S, Mann BE, Sanguinetti G,
Poole RK. CO-Releasing Molecules Have Nonheme Targets in Bacteria:
Transcriptomic, Mathematical Modeling and Biochemical Analyses of CORM-3
[Ru(CO)3Cl(glycinate)] Actions on a Heme-Deficient Mutant of Escherichia coli.
Antioxid Redox Signal. 2015 Jul 10;23(2):148-62. doi: 10.1089/ars.2014.6151. Epub
2015 Apr 28. PubMed PMID: 25811604; PubMed Central PMCID: PMC4492677.<br />
4: Tinajero-Trejo M, Denby KJ, Sedelnikova SE, Hassoubah SA, Mann BE, Poole RK.
Carbon monoxide-releasing molecule-3 (CORM-3; Ru(CO)3Cl(glycinate)) as a tool to
study the concerted effects of carbon monoxide and nitric oxide on bacterial
flavohemoglobin Hmp: applications and pitfalls. J Biol Chem. 2014 Oct
24;289(43):29471-82. doi: 10.1074/jbc.M114.573444. Epub 2014 Sep 5. PubMed PMID:
25193663; PubMed Central PMCID: PMC4207967. <br />
5: Rana N, McLean S, Mann BE, Poole RK. Interaction of the carbon
monoxide-releasing molecule Ru(CO)3Cl(glycinate) (CORM-3) with Salmonella
enterica serovar Typhimurium: in situ measurements of carbon monoxide binding by
integrating cavity dual-beam spectrophotometry. Microbiology. 2014 Dec;160(Pt
12):2771-9. doi: 10.1099/mic.0.081042-0. Epub 2014 Aug 1. PubMed PMID: 25085864. <br />
6: Nielsen VG, Garza JI. Comparison of the effects of CORM-2, CORM-3 and CORM-A1
on coagulation in human plasma. Blood Coagul Fibrinolysis. 2014 Dec;25(8):801-5.
doi: 10.1097/MBC.0000000000000146. PubMed PMID: 25058038.<br />
7: Long R, Salouage I, Berdeaux A, Motterlini R, Morin D. CORM-3, a water soluble
CO-releasing molecule, uncouples mitochondrial respiration via interaction with
the phosphate carrier. Biochim Biophys Acta. 2014 Jan;1837(1):201-9. doi:
10.1016/j.bbabio.2013.10.002. Epub 2013 Oct 23. PubMed PMID: 24161358.

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