For research use only. Not for therapeutic Use.
CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis[1][2][3].
CORM-401 (100 μM; 1h) induces the NO production in endothelial EA.hy926 cells[1].?
CORM-401 (30 μM) induces peak-like calcium signal and augmentes coupling of endoplasmic reticulum and plasmalemmal store-operated calcium channels[1].?
CORM-401 (50 μM; 1h) significantly reduces TNF-α/CHX and H2O2-induced ROS production and cell death[2].?
CORM-401 (0.5, 1 mM) induces a persistent increase in the oxygen consumption rate in endothelial EA.hy926 cells[3].?
CORM-401 (10, 30, 100 μM) induces a concentration-dependent increase in OCR and a simultaneous decrease in ECAR[3].
| Catalog Number | I006190 |
| CAS Number | 1001015-18-4 |
| Molecular Formula | C8H6MnNO6S2 |
| Purity | ≥95% |
| Reference | [1]. Kaczara P, et al. CORM-401 induces calcium signalling, NO increase and activation of pentose phosphate pathway in endothelial cells. FEBS J. 2018 Apr;285(7):1346-1358. [2]. Babu D, et al. Differential Effects of CORM-2 and CORM-401 in Murine Intestinal Epithelial MODE-K Cells under Oxidative Stress. Front Pharmacol. 2017 Feb 8;8:31. [3]. Kaczara P, et al. Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: A role for mitoBKCa channels. Biochim Biophys Acta. 2015 Oct;1847(10):1297-309. |
