Cortexolone 17 alpha-propionate

• CAT Number: I002500
• CAS Number: 19608-29-8
• Molecular Formula: C24H34O5
• Molecular Weight: 402.52
• Purity: 95%
• Synonyms: [(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate
• Target: Androgen Receptor
• Target Protein: P10275,,,
• Solubility: 10 mM in DMSO
• Appearance: Solid
• Storage: Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
• InChI: InChI=1S/C24H34O5/c1-4-21(28)29-24(20(27)14-25)12-9-19-17-6-5-15-13-16(26)7-10-22(15,2)18(17)8-11-23(19,24)3/h13,17-19,25H,4-12,14H2,1-3H3/t17-,18+,19+,22+,23+,24+/m1/s1
• InChIKey: GPNHMOZDMYNCPO-PDUMRIMRSA-N
• SMILES: CCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)C(=O)CO

Clascoterone（Cat No.:I002500）, known by various names such as Winlevi, Cortexolone 17 alpha-propionate, Cortexolone 17α-propionate, or CB-03-01, is a localized and peripherally selective androgen receptor (AR) antagonist. It works by inhibiting the binding of androgens, such as dihydrotestosterone (DHT), to the androgen receptors in the skin. This mechanism makes it useful in the treatment of acne, as it helps to reduce sebum production and inflammation associated with the condition. Clascoterone offers a targeted approach to managing acne and is available as a topical medication.