Corynoxine

• CAT Number: I004584
• CAS Number: 6877-32-3
• Molecular Formula: C22H28N2O4
• Molecular Weight: 384.48
• Purity: ≥95%
• Target: Autophagy
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IUPAC Name: methyl (E)-2-[(3S,6/'S,7/'S,8/'aS)-6/'-ethyl-2-oxospiro[1H-indole-3,1/'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7/'-yl]-3-methoxyprop-2-enoate
• InChI: InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15+,19+,22+/m1/s1
• InChIKey: DAXYUDFNWXHGBE-NRAMRBJXSA-N
• SMILES: CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O

Corynoxine(CAT: I004584) is a natural autophagy enhancer isolated from the Uncaria species, particularly Uncaria rhynchophylla, commonly used in traditional Chinese medicine. It promotes autophagy, the process by which cells degrade and recycle their components, by modulating key signaling pathways such as AMPK/mTOR. Corynoxine has been studied for its neuroprotective effects, showing promise in models of neurodegenerative diseases like Parkinson’s and Alzheimer’s, where enhanced autophagy may help clear toxic protein aggregates. In addition to its neuroprotective potential, Corynoxine exhibits anti-inflammatory and antioxidant properties, making it a compound of interest in biomedical research for its therapeutic potential in aging and neurodegeneration.