For research use only. Not for therapeutic Use.
Costunolide (CAT: I004060) is a natural sesquiterpene lactone that is found in several medicinal plants, including Saussurea lappa and Magnolia grandiflora. It exhibits various pharmacological activities, including anti-inflammatory, antioxidant, anticancer, and immunomodulatory effects. Costunolide has been studied for its potential therapeutic applications in the treatment of inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. It also shows promise as an anticancer agent, as it has demonstrated cytotoxic effects against various cancer cell lines and exhibits potential in inhibiting cancer cell proliferation and inducing apoptosis. Furthermore, costunolide has been investigated for its neuroprotective and hepatoprotective properties. However, further research is needed to fully understand its mechanisms of action and evaluate its clinical potential.
| Catalog Number | I004060 |
| CAS Number | 553-21-9 |
| Synonyms | (+)-Costunolide;Costunolid; Costus lactone; NSC 106404; |
| Molecular Formula | C15H20O2 |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Solubility | DMSO > 49 mg/ml |
| Storage | 3 years -20C powder |
| IC50 | 6.2 - 9.8 ug/mL(sarcoma cells viability) |
| InChIKey | HRYLQFBHBWLLLL-GRFSRWIASA-N |
| Reference | </br>1:Costunolide increases osteoblast differentiation via ATF4-dependent HO-1 expression in C3H10T1/2 cells. Jeon WJ, Kim KM, Kim EJ, Jang WG.Life Sci. 2017 Apr 20. pii: S0024-3205(17)30160-1. doi: 10.1016/j.lfs.2017.04.012. [Epub ahead of print] PMID: 28435036 </br>2:Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway. Peng Z, Wang Y, Fan J, Lin X, Liu C, Xu Y, Ji W, Yan C, Su C.Sci Rep. 2017 Jan 24;7:41254. doi: 10.1038/srep41254. PMID: 28117370 Free PMC Article</br>3:Costunolide, a sesquiterpene lactone, inhibits the differentiation of pro-inflammatory CD4<sup>+</sup> T cells through the modulation of mitogen-activated protein kinases. Park E, Song JH, Kim MS, Park SH, Kim TS.Int Immunopharmacol. 2016 Nov;40:508-516. doi: 10.1016/j.intimp.2016.10.006. Epub 2016 Oct 15. PMID: 27756053 </br>4:Protective Effects of Costunolide against Hydrogen Peroxide-Induced Injury in PC12 Cells. Cheong CU, Yeh CS, Hsieh YW, Lee YR, Lin MY, Chen CY, Lee CH.Molecules. 2016 Jul 9;21(7). pii: E898. doi: 10.3390/molecules21070898. PMID: 27409597 Free Article</br>5:/Click/ reaction mediated synthesis of costunolide and dehydrocostuslactone derivatives and evaluation of their cytotoxic activity. Pavan Kumar Ch, Devi A, Ashok Yadav P, Rao Vadaparthi R, Shankaraiah G, Sowjanya P, Jain N, Suresh Babu K.J Asian Nat Prod Res. 2016 Nov;18(11):1063-78. doi: 10.1080/10286020.2016.1193012. Epub 2016 Jun 22. PMID: 27329166 </br>6:Costunolide, an active sesquiterpene lactone, induced apoptosis via ROS-mediated ER stress and JNK pathway in human U2OS cells. Zhang C, Lu T, Wang GD, Ma C, Zhou YF.Biomed Pharmacother. 2016 May;80:253-9. doi: 10.1016/j.biopha.2016.03.031. Epub 2016 Apr 1. PMID: 27133064 </br>7:Costunolide Induces Apoptosis through Generation of ROS and Activation of P53 in Human Esophageal Cancer Eca-109 Cells. Hua P, Sun M, Zhang G, Zhang Y, Song G, Liu Z, Li X, Zhang X, Li B.J Biochem Mol Toxicol. 2016 Sep;30(9):462-9. doi: 10.1002/jbt.21810. Epub 2016 Apr 14. PMID: 27078502 </br>8:Costunolide induces G1/S phase arrest and activates mitochondrial-mediated apoptotic pathways in SK-MES 1 human lung squamous carcinoma cells. Hua P, Zhang G, Zhang Y, Sun M, Cui R, Li X, Li B, Zhang X.Oncol Lett. 2016 Apr;11(4):2780-2786. Epub 2016 Mar 1. PMID: 27073552 Free PMC Article</br>9:Evaluation of protective effects of costunolide and dehydrocostuslactone on ethanol-induced gastric ulcer in mice based on multi-pathway regulation. Zheng H, Chen Y, Zhang J, Wang L, Jin Z, Huang H, Man S, Gao W.Chem Biol Interact. 2016 Apr 25;250:68-77. doi: 10.1016/j.cbi.2016.03.003. Epub 2016 Mar 10. PMID: 26970604 </br>10:Costunolide induces lung adenocarcinoma cell line A549 cells apoptosis through ROS (reactive oxygen species)-mediated endoplasmic reticulum stress. Wang Z, Zhao X, Gong X.Cell Biol Int. 2016 Mar;40(3):289-97. doi: 10.1002/cbin.10564. Epub 2016 Jan 21. PMID: 26609913 |
