Cot inhibitor-1

• CAT Number: I005459
• CAS Number: 915365-57-0
• Molecular Formula: C27H27Cl2FN8
• Molecular Weight: 553.47
• Purity: ≥95%
• Synonyms: 6-[[1-[2-(azepan-1-yl)ethyl]triazol-4-yl]methylamino]-8-chloro-4-(3-chloro-4-fluoroanilino)quinoline-3-carbonitrile
• Target: MAP3K
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C

Cot inhibitor-1 is a COT/Tpl2 inhibitor.

Reference

[1]. Wu, Junjun et al Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-production in human whole blood.Bioorganic & Medicinal Chemistry Letters (2009), 19(13), 3485-3488.