Cot inhibitor-1

• CAT Number: I005459
• CAS Number: 915365-57-0
• Molecular Formula: C27H27Cl2FN8
• Molecular Weight: 553.47
• Purity: ≥95%
• Synonyms: 6-[[1-[2-(azepan-1-yl)ethyl]triazol-4-yl]methylamino]-8-chloro-4-(3-chloro-4-fluoroanilino)quinoline-3-carbonitrile
• Target: MAP3K
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C27H27Cl2FN8/c28-23-12-19(5-6-25(23)30)34-26-18(14-31)15-33-27-22(26)11-20(13-24(27)29)32-16-21-17-38(36-35-21)10-9-37-7-3-1-2-4-8-37/h5-6,11-13,15,17,32H,1-4,7-10,16H2,(H,33,34)
• InChIKey: ZWFKJFUFYPOTKL-UHFFFAOYSA-N
• SMILES: C1CCCN(CC1)CCN2C=C(N=N2)CNC3=CC4=C(C(=CN=C4C(=C3)Cl)C#N)NC5=CC(=C(C=C5)F)Cl

Cot inhibitor-1（Cat No.:I005459）is an experimental small molecule compound that targets Cot, a kinase involved in various signaling pathways related to inflammation, cell survival, and cancer. Cot (also known as Tpl2) plays a role in regulating immune responses and promoting tumorigenesis in certain cancers. By inhibiting Cot, Cot inhibitor-1 aims to disrupt these pathways, potentially reducing inflammation and inhibiting tumor growth. This compound is being studied for its therapeutic potential in treating inflammatory diseases, autoimmune disorders, and certain cancers. However, its safety and effectiveness are still being evaluated in preclinical and clinical trials.