For research use only. Not for therapeutic Use.
Cot inhibitor-2 (Cat.No:I005458) is a potent and selective inhibitor of the protein kinase C-terminal kinase (Cot/Tpl2). By targeting Cot/Tpl2, this compound modulates inflammatory signaling pathways, making it a promising candidate for treating various inflammatory diseases, such as rheumatoid arthritis and cancer. Further research is underway to explore its therapeutic potential.
| Catalog Number | I005458 |
| CAS Number | 915363-56-3 |
| Synonyms | 8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethylpiperidin-4-yl)triazol-4-yl]methylamino]quinoline-3-carbonitrile |
| Molecular Formula | C26H25Cl2FN8 |
| Purity | ≥95% |
| Target | MAP3K |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethylpiperidin-4-yl)triazol-4-yl]methylamino]quinoline-3-carbonitrile |
| InChI | InChI=1S/C26H25Cl2FN8/c1-2-36-7-5-20(6-8-36)37-15-19(34-35-37)14-31-18-9-21-25(33-17-3-4-24(29)22(27)10-17)16(12-30)13-32-26(21)23(28)11-18/h3-4,9-11,13,15,20,31H,2,5-8,14H2,1H3,(H,32,33) |
| InChIKey | PHNZIIMWDVXPGG-UHFFFAOYSA-N |
| SMILES | CCN1CCC(CC1)N2C=C(N=N2)CNC3=CC4=C(C(=CN=C4C(=C3)Cl)C#N)NC5=CC(=C(C=C5)F)Cl |
| Reference | [1]. Wu, Junjun et al Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-production in human whole blood. Bioorganic & Medicinal Chemistry Letters (2009), 19(13), 3485-3488. |
