For research use only. Not for therapeutic Use.
Cotrimoxazole(CAT: R063307) is a combination antibiotic consisting of sulfamethoxazole and trimethoprim. It works by inhibiting two sequential steps in the bacterial folic acid synthesis pathway: sulfamethoxazole inhibits dihydropteroate synthase, while trimethoprim inhibits dihydrofolate reductase. This dual inhibition effectively prevents the growth and replication of a broad range of gram-positive and gram-negative bacteria. Cotrimoxazole is commonly used in the treatment of urinary tract infections, respiratory infections, and certain types of gastrointestinal infections. It is relevant in Infection Disease Research due to its broad-spectrum activity and application in treating bacterial infections resistant to other antibiotics.
| CAS Number | 8064-90-2 |
| Synonyms | 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine |
| Molecular Formula | C24H29N7O6S |
| Purity | ≥95% |
| IUPAC Name | 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine |
| InChI | InChI=1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13) |
| InChIKey | WZRJTRPJURQBRM-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N.COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N |
