For research use only. Not for therapeutic Use.
Coumarin boronic acid (CBA) (Item No. <span class=/itemid/>14051</span>) is a fluorescent probe that can be used to detect peroxynitrite (Item No. <span class=/itemid/>81565</span>), hypochlorous acid, and hydrogen peroxide. It reacts directly and rapidly with peroxynitrite at an exponentially faster rate (k = 1.1 μM/s) than hydrogen peroxide (k = 1.5 M/s) and moderately faster rate than hypochlorous acid. Peroxynitrite oxidizes CBA stoichiometrically at a 1:1 ratio into a fluorescent product that can be examined at an excitation of 332 nm and emission > 400 nm. The pinacolate ester of coumarin boronic acid can react with peroxynitrite, hypochlorous acid, and hydrogen peroxide in a similar manner to CBA, yet is formulated for improved solubility.
| Catalog Number | R009388 |
| CAS Number | 190788-61-5 |
| Synonyms | 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-1-benzopyran-2-one; |
| Molecular Formula | C15H17BO4 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)chromen-2-one |
| InChI | InChI=1S/C15H17BO4/c1-14(2)15(3,4)20-16(19-14)11-7-5-10-6-8-13(17)18-12(10)9-11/h5-9H,1-4H3 |
| InChIKey | BSNRAQZLNMHAOJ-UHFFFAOYSA-N |
| SMILES | B1(OC(C(O1)(C)C)(C)C)C2=CC3=C(C=C2)C=CC(=O)O3 |
