CP-10

• CAT Number: I018720
• CAS Number: 2366268-80-4
• Molecular Formula: C₄₄H₄₉N₁₃O₇
• Molecular Weight: 871.94
• Purity: ≥95%
• Target: Cell Cycle/DNA Damage
• IUPAC Name: 4-[2-[2-[4-[[4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazin-1-yl]methyl]triazol-1-yl]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
• InChI: InChI=1S/C44H49N13O7/c1-26-32-23-47-44(50-39(32)56(29-6-3-4-7-29)42(62)37(26)27(2)58)48-35-12-10-30(22-46-35)54-17-15-53(16-18-54)24-28-25-55(52-51-28)19-21-64-20-14-45-33-9-5-8-31-38(33)43(63)57(41(31)61)34-11-13-36(59)49-40(34)60/h5,8-10,12,22-23,25,29,34,45H,3-4,6-7,11,13-21,24H2,1-2H3,(H,49,59,60)(H,46,47,48,50)
• InChIKey: PACRWHUPEPCFHX-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCN(CC4)CC5=CN(N=N5)CCOCCNC6=CC=CC7=C6C(=O)N(C7=O)C8CCC(=O)NC8=O)C9CCCC9)C(=O)C

CP-10 (Cat.No:I018720) is a potent and selective PROTAC compound that exhibits significant CDK6 degradation potential (DC50 = 2.1nM). It effectively inhibits the proliferation of several hematopoietic malignancies, including multiple myeloma, and retains the ability to degrade mutant and overexpressed CDK6. CP-10 shows promising results in preclinical studies, with high degradation of CDK6 in human glioblastoma cells and a notable cell inhibition potential in multiple myeloma and mantle cell lymphoma cells.

Reference

[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.