For research use only. Not for therapeutic Use.
Potent and NR2B selective antagonist of NMDA glutamate receptors.
CP 101606 is also available as its parent compound (Axon 2254)
| Catalog Number | I037466 |
| CAS Number | 188591-67-5 |
| Molecular Formula | C20H25NO3.CH4O3S |
| Purity | ≥95% |
| IUPAC Name | 1-[(1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol;methanesulfonic acid |
| InChI | InChI=1S/C20H25NO3.CH4O3S/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17;1-5(2,3)4/h2-10,15,19,22-24H,11-14H2,1H3;1H3,(H,2,3,4)/t15-,19+;/m0./s1 |
| SMILES | C[C@@H]([C@H](C1=CC=C(C=C1)O)O)N2CCC(CC2)(C3=CC=CC=C3)O.CS(=O)(=O)O |
| Reference | K Taniguchi et al. Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist. Br. J. Pharmacol. 1997, 122, 809–812.
FS. Menniti et al. CP-101,606: An NR2B-Selective NMDA Receptor Antagonist. CNS Drug Rev. 1998, 4(4), 307-322.
L. Yurkewicz et al. The effect of the selective NMDA receptor antagonist traxoprodil in the treatment of traumatic brain injury. J. Neurotrauma. 2005, 22(12), 1428-43.
JG Nutt et al. Effects of a NR2B selective NMDA glutamate antagonist, CP-101,606, on dyskinesia and parkinsonist. Mov. Disord. 2008, 23(13), 1860-1866. |
