For research use only. Not for therapeutic Use.
CP-113818 is a potent cholesterol acyltransferase (ACAT) inhibitor. CP-113818 can be used for the research of Alzheimer’s disease[1].
CP-113818 inhibits Aβ production in cell-based experiments[1].
CP-113818 (0-7.1 mg/kg/day) markedly reduces amyloid pathology in a mouse model of Alzheimer’s disease[1].
| Catalog Number | I025128 |
| CAS Number | 135025-12-6 |
| Synonyms | (2S)-2-hexylsulfanyl-N-[6-methyl-2,4-bis(methylsulfanyl)pyridin-3-yl]decanamide |
| Molecular Formula | C24H42N2OS3 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H42N2OS3/c1-6-8-10-12-13-14-16-20(30-17-15-11-9-7-2)23(27)26-22-21(28-4)18-19(3)25-24(22)29-5/h18,20H,6-17H2,1-5H3,(H,26,27)/t20-/m0/s1 |
| InChIKey | XAMYAYIMCKELIP-FQEVSTJZSA-N |
| SMILES | CCCCCCCCC(C(=O)NC1=C(C=C(N=C1SC)C)SC)SCCCCCC |
| Reference | [1]. Hutter-Paier B, et al. The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer’s disease. Neuron. 2004 Oct 14;44(2):227-38. |
