For research use only. Not for therapeutic Use.
Selective 5-HT agonist which binds with high affinity to central 5-HT1D receptors. In functional studies CP 135807 produces dose-dependent decreases in extracellular serotonin
| Catalog Number | R053488 |
| CAS Number | 151272-90-1 |
| Molecular Formula | C19H21N5O2 |
| Purity | ≥95% |
| IUPAC Name | 3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-N-(3-nitropyridin-2-yl)-1H-indol-5-amine |
| InChI | InChI=1S/C19H21N5O2/c1-23-9-3-4-15(23)10-13-12-21-17-7-6-14(11-16(13)17)22-19-18(24(25)26)5-2-8-20-19/h2,5-8,11-12,15,21H,3-4,9-10H2,1H3,(H,20,22)/t15-/m1/s1 |
| SMILES | CN1CCC[C@@H]1CC2=CNC3=C2C=C(C=C3)NC4=C(C=CC=N4)[N+](=O)[O-] |
| Reference | RS Mansbach et al. CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon. Psychopharm. (Berl). 1996, 128(3), 313-319.
H Rollema et al. Combined administration of a 5-hydroxytryptamine (5-HT)1D antagonist and a 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo. J. Neurochem. 1996, 67(5), 2204-2207. |
