For research use only. Not for therapeutic Use.
Corticotropin-releasing factor CRF1 antagonist
| Catalog Number | R053492 |
| CAS Number | 257639-98-8 |
| Molecular Formula | C23H32N4.HCl |
| Purity | ≥95% |
| IUPAC Name | N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine;hydrochloride |
| InChI | InChI=1S/C23H32N4.ClH/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5;/h12-14H,8-11H2,1-7H3;1H |
| SMILES | CCCCN(CC)C1=NC(=NC2=C1C(=CN2C3=C(C=C(C=C3C)C)C)C)C.Cl |
| Reference | SPH Alexander et al. Guide to Receptors and Channels (GRAC), 2nd edition (2007 revision). Br. J. Pharmacol. 2007, 150 (Suppl. 1), S1–S168.
Lundkist et al. A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic activity. Eur. J. Pharmacol. 1996, 309, 195.
Schulz et al. CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proc. Natl. Acad. Sci. USA 1996, 93 10477.
Hodgson et al. Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression. Pharmacol. Biochem. Behav. 2007, 86, 431. |
