CP 24,879 (hydrochloride)

• CAT Number: R042530
• CAS Number: 10141-51-2
• Molecular Formula: C11H18ClNO
• Molecular Weight: 215.721
• Purity: ≥95%
• Synonyms: p-(Isopentyloxy)-aniline
• Storage: -20°C
• IUPAC Name: 4-(3-methylbutoxy)aniline;hydrochloride
• InChI: InChI=1S/C11H17NO.ClH/c1-9(2)7-8-13-11-5-3-10(12)4-6-11;/h3-6,9H,7-8,12H2,1-2H3;1H
• InChIKey: GFESZSNFRSACMU-UHFFFAOYSA-N
• SMILES: CC(C)CCOC1=CC=C(C=C1)N.Cl

Essential fatty acid deficiency symptoms include immune system depression and a general state of inflammatory inhibition. CP 24,879 is an inhibitor of arachidonic acid biosynthesis acting via the inhibition of Δ Mice injected with CP 24,879 at 3 mg/kg had a reduction of liver arachidonate content of approximately 50%. Murine mastocytoma cells treated with 5 µM CP 24,879 showed increased mead acid content and nearly complete ablation of leukotriene C4 synthesis, consistent with a desaturase inhibition-<wbr></wbr>induced state of essential fatty acid deficiency.

Reference

1.Obukowicz, M.G.,Raz, A.,Pyla, P.D., et al. Identification and characterization of a novel Δ6/Δ5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochemical Pharmacology 55, 1045-1058 (1998).