For research use only. Not for therapeutic Use.
CP-312 is an activator of the antioxidant defense response. It acts by inducing heme oxygenase-1 and protecting human iPSC-derived cardiomyocytes from oxidative stress.
| Catalog Number | I025136 |
| CAS Number | 895470-67-4 |
| Synonyms | CP-312; CP 312; CP312; Cardioprotectant 312; |
| Molecular Formula | C16H12ClN3OS2 |
| Purity | 98% |
| Target | NF-κB |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-((4-Chlorophenyl)thio)-N-(4-(pyridin-2-yl)thiazol-2-yl)acetamide |
| InChI | InChI=1S/C16H12ClN3OS2/c17-11-4-6-12(7-5-11)22-10-15(21)20-16-19-14(9-23-16)13-3-1-2-8-18-13/h1-9H,10H2,(H,19,20,21) |
| InChIKey | KAWIOCMUARENDQ-UHFFFAOYSA-N |
| SMILES | O=C(NC1=NC(C2=NC=CC=C2)=CS1)CSC3=CC=C(Cl)C=C3 |
| Reference | 1: Kirby RJ, Divlianska DB, Whig K, Bryan N, Morfa CJ, Koo A, Nguyen KH, Maloney P, Peddibhotla S, Sessions EH, Hershberger PM, Smith LH, Malany S. Discovery of Novel Small-Molecule Inducers of Heme Oxygenase-1 That Protect Human iPSC-Derived Cardiomyocytes from Oxidative Stress. J Pharmacol Exp Ther. 2018 Jan;364(1):87-96. doi: 10.1124/jpet.117.243717. Epub 2017 Nov 3. PubMed PMID: 29101218. |
