For research use only. Not for therapeutic Use.
CP-339818（Cat No.:I006210）is a selective small molecule antagonist of the neurokinin-1 (NK1) receptor, which plays a role in pain signaling and emotional regulation. By blocking the NK1 receptor, CP-339818 has shown potential in preclinical studies as a treatment for conditions like chronic pain, depression, and anxiety. The compound has been explored for its ability to reduce the effects of substance P, a neurotransmitter involved in pain perception and stress responses. While early research showed promise, further clinical trials are necessary to determine its efficacy and safety for human use in various neurological and psychiatric disorders.
| Catalog Number | I006210 |
| CAS Number | 185855-91-8 |
| Synonyms | CP-339818; CP 339818; CP339818; CP-339818 HCl; CP339818HCl.;N-pentyl-1-(phenylmethyl)quinolin-4-imine |
| Molecular Formula | C21H25ClN2 |
| Purity | ≥95% |
| Target | KV1.3 channel antagonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term ,or -20 °C for long term |
| IUPAC Name | 1-benzyl-N-pentylquinolin-4-imine;hydrochloride |
| InChI | InChI=1S/C21H24N2.ClH/c1-2-3-9-15-22-20-14-16-23(17-18-10-5-4-6-11-18)21-13-8-7-12-19(20)21;/h4-8,10-14,16H,2-3,9,15,17H2,1H3;1H |
| InChIKey | JIRISCAPZWLWCG-UHFFFAOYSA-N |
| SMILES | CCCCCN=C1C=CN(C2=CC=CC=C12)CC3=CC=CC=C3.Cl |
| Reference | </br>1: Sforna L, D/’Adamo MC, Servettini I, Guglielmi L, Pessia M, Franciolini F, Catacuzzeno L. Expression and function of a CP339,818-sensitive K⁺ current in a subpopulation of putative nociceptive neurons from adult mouse trigeminal ganglia. J Neurophysiol. 2015 Apr 1;113(7):2653-65. doi: 10.1152/jn.00379.2014. PubMed PMID: 25652918; PubMed Central PMCID: PMC4416569. |
