For research use only. Not for therapeutic Use.
CP-424174 (CAT: I006215) is a potent cytokine release inhibitory drug (CRID) that demonstrates an IC50 of 210 nM. By effectively modulating cytokine release, CP-424174 functions as an essential regulator of immune responses. Specifically, it acts as a suppressor of IL-1β secretion, effectively hindering the post-translational processing and subsequent release of IL-1β in human monocytes, especially in response to stimuli such as lipopolysaccharides (LPS) and adenosine triphosphate (ATP).
| Catalog Number | I006215 |
| CAS Number | 210825-31-3 |
| Synonyms | CP-424174; CP 424174; CP424174; CP-424,174; CP 424,174; CP424,174.;N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide |
| Molecular Formula | C22H29ClN2O4S |
| Purity | ≥95% |
| Target | NOD-like Receptor (NLR) |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term ,or -20 °C for long term |
| IC50 | IC50 = 210 Nm |
| IUPAC Name | 1-[4-chloro-2,6-di(propan-2-yl)phenyl]-3-[3-(2-hydroxypropan-2-yl)phenyl]sulfonylurea |
| InChI | InChI=1S/C22H29ClN2O4S/c1-13(2)18-11-16(23)12-19(14(3)4)20(18)24-21(26)25-30(28,29)17-9-7-8-15(10-17)22(5,6)27/h7-14,27H,1-6H3,(H2,24,25,26) |
| InChIKey | YRSBLSHMKVQWHP-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CC(=CC(=C1NC(=O)NS(=O)(=O)C2=CC=CC(=C2)C(C)(C)O)C(C)C)Cl |
| Reference | </br>1:Perregaux DG, McNiff P, Laliberte R, Hawryluk N, Peurano H, Stam E, Eggler J, Griffiths R, Dombroski MA, Gabel CA. Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J Pharmacol Exp Ther. 2001 Oct;299(1):187-97. PubMed PMID: 11561079.</br>2: Perregaux DG, Bhavsar K, Contillo L, Shi J, Gabel CA. Antimicrobial peptides initiate IL-1 beta posttranslational processing: a novel role beyond innate immunity. J Immunol. 2002 Mar 15;168(6):3024-32. PubMed PMID: 11884475. |
