For research use only. Not for therapeutic Use.
CP-465022 (Cat.No:I006223) is a potent, and selective noncompetitive AMPA receptor antagonist. It provides neuroprotective efficacy after cerebral ischemia on the basis of the activity in experimental ischemia models.
| Catalog Number | I006223 |
| CAS Number | 199655-36-2 |
| Synonyms | CP-465022; CP 465022; CP465022; UNII-4582JTR93Y.;4(3H)-Quinazolinone, 3-(2-chlorophenyl)-2-(2-(6-((diethylamino)methyl)-2-pyridinyl)ethenyl)-6-fluoro- |
| Molecular Formula | C26H24ClFN4O.HCl |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at RT |
| IUPAC Name | 3-(2-chlorophenyl)-2-[(E)-2-[6-(diethylaminomethyl)pyridin-2-yl]ethenyl]-6-fluoroquinazolin-4-one |
| InChI | InChI=1S/C26H24ClFN4O/c1-3-31(4-2)17-20-9-7-8-19(29-20)13-15-25-30-23-14-12-18(28)16-21(23)26(33)32(25)24-11-6-5-10-22(24)27/h5-16H,3-4,17H2,1-2H3/b15-13+ |
| InChIKey | HYHNPUGUPISSQO-FYWRMAATSA-N |
| SMILES | CCN(CC)Cc1cccc(n1)/C=C/c2nc3ccc(cc3c(=O)n2c4ccccc4Cl)F |
| Reference | </br>1:Mosley CA, Acker TM, Hansen KB, Mullasseril P, Andersen KT, Le P, Vellano KM, Bräuner-Osborne H, Liotta DC, Traynelis SF. Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. J Med Chem. 2010 Aug 12;53(15):5476-90. doi: 10.1021/jm100027p. PubMed PMID: 20684595; PubMed Central PMCID: PMC2920070. |
