CP-690550

For research use only. Not for therapeutic Use.

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CP-690550(Cat No.:A000725), also known as Tofacitinib, is an oral Janus kinase (JAK) inhibitor used to treat autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It works by inhibiting the JAK-STAT signaling pathway, which plays a crucial role in the immune response and inflammation. By blocking this pathway, Tofacitinib reduces inflammation and immune system activity, alleviating symptoms of these chronic diseases. It is effective in improving joint function and slowing disease progression. Common side effects include infections, elevated liver enzymes, and lipid levels. Regular monitoring is necessary to manage potential risks.


Catalog Number A000725
CAS Number 477600-75-2
Synonyms

Tofacitinib base;CP-690550;Tasocitinib;

Molecular Formula C16H20N6O
Purity ≥95%
Target JAK
Solubility Soluble in DMSO
Storage 3 years -20C powder
IUPAC Name 3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile
InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1
InChIKey UJLAWZDWDVHWOW-YPMHNXCESA-N
SMILES C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N

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