CP-724714

• CAT Number: I002211
• CAS Number: 537705-08-1
• Molecular Formula: C27H27N5O3
• Molecular Weight: 469.53
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CCOC(=O)NCC=CC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OC4=CN=C(C=C4)C)C

CP-724714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc in cell-free assays. Phase 2.

Reference

[1] Jani JP, et al. Cancer Res, 2007, 67(20), 9887-9893.
[2] Feng B, et al. Toxicol Sci, 2009, 108(2), 492-500.