CP-724714

• CAT Number: I003412
• CAS Number: 383432-38-0
• Molecular Formula: C27H27N5O3
• Molecular Weight: 469.5
• Purity: ≥95%
• Synonyms: 2-methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]-acetamide
• Target: HER2/ErbB2
• Solubility: DMSO: ≥ 50 mg/mL
• Storage: Store at -20°C
• IC50: 10 nM [1]
• IUPAC Name: 2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide
• InChI: InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+
• InChIKey: LLVZBTWPGQVVLW-SNAWJCMRSA-N
• SMILES: O=C(COC)NC/C=C/C1=CC=C(N=CN=C2NC3=CC=C(OC4=CN=C(C)C=C4)C(C)=C3)C2=C1

CP-724714 (Cat.No:I003412) is a small molecule inhibitor that targets the tyrosine kinase activity of the platelet-derived growth factor receptor (PDGFR). It has shown efficacy in inhibiting tumor growth and angiogenesis in preclinical studies. Further research is needed to evaluate its potential as an anti-cancer therapeutic agent.

Reference

[1]. Jani JP, et al. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res, 2007, 67(20), 9887-9893.
[2]. Feng B, et al. Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714. Toxicol Sci, 2009, 108(2), 492-500.