CP-724714

• CAT Number: I003412
• CAS Number: 383432-38-0
• Molecular Formula: C27H27N5O3
• Molecular Weight: 469.55
• Purity: ≥95%
• Synonyms: 2-methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]-acetamide
• Target: Protein Tyrosine Kinase/RTK
• Solubility: DMSO: ≥ 50 mg/mL
• Storage: Store at -20°C
• IC50: 10 nM [1]
• IUPAC Name: 2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide
• InChI: InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+
• InChIKey: LLVZBTWPGQVVLW-SNAWJCMRSA-N
• SMILES: O=C(COC)NC/C=C/C1=CC=C(N=CN=C2NC3=CC=C(OC4=CN=C(C)C=C4)C(C)=C3)C2=C1

CP-724714 (Cat.No:I003412) is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It is primarily investigated in the context of cancer research, particularly for targeting EGFR-driven tumors. By blocking the EGFR signaling pathway, CP-724714 may inhibit tumor growth, progression, and metastasis. This compound has shown promise in preclinical studies, demonstrating potential therapeutic benefits in cancers such as breast, lung, and head and neck carcinomas. It continues to be explored in clinical trials for its efficacy and safety.