For research use only. Not for therapeutic Use.
CP-74006 (Cat.No:I011879) is a selective D5D inhibitor. CP-74006 potently blocks the Delta5D activity with an IC(50) value of 20 nM and simplifies the metabolism of [1-(14)C]-alpha-linolenate (C18:3, cis-9,12,15) by accumulating (14)C-eicosatetraenoic acid (C20:4, cis-8,11,14,17) as the major (14)C-eicosatrienoic acid (C20:3, cis-11,14,17) and (14)C-docosatetraenoic acid (C22:4, cis-10,13,16,19) as the minor metabolites through Delta6 desaturation and elongation.
| Catalog Number | I011879 |
| CAS Number | 4943-86-6 |
| Synonyms | CP-74006; CP74006; CP 74006.;2-amino-N-(4-chlorophenyl)benzamide |
| Molecular Formula | C13H11ClN2O |
| Purity | ≥95% |
| Target | D5D inhibitor |
| Solubility | Soluble in DMSO |
| Storage | Store at 2-8 °C |
| IUPAC Name | 2-amino-N-(4-chlorophenyl)benzamide |
| InChI | InChI=1S/C13H11ClN2O/c14-9-5-7-10(8-6-9)16-13(17)11-3-1-2-4-12(11)15/h1-8H,15H2,(H,16,17) |
| InChIKey | RHCJFZKQYODIDI-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)Cl)N |
| Reference | </br>1: Zhang L, Ramtohul Y, Gagné S, Styhler A, Wang H, Guay J, Huang Z. A</br> multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6,</br> and delta-9 desaturase and elongase inhibitors. J Biomol Screen. 2010</br> Feb;15(2):169-76. doi: 10.1177/1087057109356208. Epub 2010 Jan 19. PubMed PMID:</br> 20086206.</br> </br> |
