For research use only. Not for therapeutic Use.
Potent and selective PPARα agonist (Ki=24.5 nM and >10 µM for PPARβ and PPARγ), supporting robust recruitment of co-activator peptides in vitro. CP775146 markedly potentiates chimeric transcription systems in cell-based assays and strikingly lowers serum triglycerides in vivo
| Catalog Number | R053741 |
| CAS Number | 702680-17-9 |
| Molecular Formula | C26H33NO4 |
| Purity | ≥95% |
| IUPAC Name | 2-methyl-2-[3-[(3S)-1-[2-(4-propan-2-ylphenyl)acetyl]piperidin-3-yl]phenoxy]propanoic acid |
| InChI | InChI=1S/C26H33NO4/c1-18(2)20-12-10-19(11-13-20)15-24(28)27-14-6-8-22(17-27)21-7-5-9-23(16-21)31-26(3,4)25(29)30/h5,7,9-13,16,18,22H,6,8,14-15,17H2,1-4H3,(H,29,30)/t22-/m1/s1 |
| SMILES | CC(C)C1=CC=C(C=C1)CC(=O)N2CCC[C@H](C2)C3=CC(=CC=C3)OC(C)(C)C(=O)O |
| Reference | CD Kane et al. Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo. Mol. Pharmacol. 2009, 75(2), 296-306. |
