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125314-13-8-CP21R7 CP21R7

CP21R7

For research use only. Not for therapeutic Use.

  • CAT Number: I001003
  • CAS Number: 125314-13-8
  • Molecular Formula: C₁₉H₁₅N₃O₂
  • Molecular Weight: 317.35
  • Purity: ≥95%
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Related Small Molecules: 2-Methoxyestradiol-d5     4-O-Methyldopamine hydrochloride     Favipiravir    

<p style=/line-height:25px/>CP21R7 is a potent and selective GSK-3β inhibitor.<br>CP21R7 can inhibitor enhances the induction of KDR+precursors prior to vascular commitment.Cp21R7 compound induced the highest luciferase activity at a concentration of 3 μ M.[2] Immunofluorescence staining revealed that CP21 significantly increased total levels of intracellular -catenin. Activation of WNT signaling via GSK3 inhibition with CP21 induced commitment of hPSCs towards mesoderm. [3]</p>


Catalog Number I001003
CAS Number 125314-13-8
Synonyms

3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Molecular Formula C₁₉H₁₅N₃O₂
Purity ≥95%
Target Stem Cell/Wnt
Solubility DMSO: ≥ 34 mg/mL
Storage Store at -20°C
InChI InChI=1S/C19H15N3O2/c1-22-10-14(13-7-2-3-8-15(13)22)17-16(18(23)21-19(17)24)11-5-4-6-12(20)9-11/h2-10H,20H2,1H3,(H,21,23,24)
InChIKey RGTAEYDIDMGJLX-UHFFFAOYSA-N
SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CC(=CC=C4)N
Reference

<p style=/line-height:25px/>
<br>[1]. Sahara M et al. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitorsfrom human pluripotent stem cells, 2015 Jan, 25(1):148

<br>[2]. K. christensen et al. Method for differentiation of pluripotent stem cells into vascular bed cells. Application number, CN 201280028159, Mar 5, 2014.

<br>[3]. Christoph Patsch et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol, 2015 Aug, 17(8): 994-1003.

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