For research use only. Not for therapeutic Use.
CP26 is a small molecule inhibitor of protein dislocation from the ER lumen to the cytosol. CP26 targets the Hrd1 complex, inhibits ERAD, and induces ER stress[1].
CP26 exhibits a significant inhibitory activity against both DENV and ZIKV, providing substantial protection to the host cells against virus-induced cell death[1].
CP26 inhibits the ubiquitination and degradation of misfolded ER proteins[1].
| Catalog Number | I025133 |
| CAS Number | 500285-30-3 |
| Synonyms | 1-methyl-4-[(2,3,4,5-tetrachlorocyclopenta-2,4-dien-1-ylidene)methyl]benzene |
| Molecular Formula | C13H8Cl4 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H8Cl4/c1-7-2-4-8(5-3-7)6-9-10(14)12(16)13(17)11(9)15/h2-6H,1H3 |
| InChIKey | GLCNSQWOANYMNW-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)C=C2C(=C(C(=C2Cl)Cl)Cl)Cl |
| Reference | [1]. Jingjing Ruan, et al. A small molecule inhibitor of ER-to-cytosol protein dislocation exhibits anti-dengue and anti-Zika virus activity. Sci Rep. 2019 Jul 29;9(1):10901. |
