For research use only. Not for therapeutic Use.
CPI-4203 is a potent KDM5A inhibitor with an IC50 of 250 nM. CPI-4203 is competitive with 2-oxoglutarate (2-OG). CPI-4203 is structurally related to CPI-455 (HY-100421) but is less potent[1].
| Catalog Number | I006288 |
| CAS Number | 1628214-07-2 |
| Synonyms | 6-ethyl-5-(2-methylphenyl)-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile |
| Molecular Formula | C16H14N4O |
| Purity | ≥95% |
| InChI | InChI=1S/C16H14N4O/c1-3-12-14(13-7-5-4-6-10(13)2)19-15-11(8-17)9-18-20(15)16(12)21/h4-7,9,18H,3H2,1-2H3 |
| InChIKey | QMUCSMPNEDSGPT-UHFFFAOYSA-N |
| SMILES | CCC1=C(N=C2C(=CNN2C1=O)C#N)C3=CC=CC=C3C |
| Reference | [1]. Vinogradova M, et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol. 2016 Jul;12(7):531-8. |
