[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide

• CAT Number: P000065
• CAS Number: 313988-89-5
• Molecular Formula: C183H281N57O54S2
• Molecular Weight: 4207.66
• Purity: ≥95%

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake[1].
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide has IC50s of 530 nM, >500 nM, 51 nM for binding to the hY1, hY4, hY2 receptors[1].
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide (0.2, 2 nmol/rat) induces a high amount of food intake in a dose-dependent manner in adult male rats weighing 340-400 g[1].

Reference

[1]. C Cabrele , et al. The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats. J Biol Chem. 2000 Nov 17;275(46):36043-8.
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