For research use only. Not for therapeutic Use.
CPPG ((RS)-CPPG) is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors[1].
CPPG ((RS)-CPPG) potently reversed both L-AP4 (IC50=2.2 nM)- and L-CCG-I (IC50=46.2 nM) -mediated inhibition of forskolin-stimulated cyclic AMP accumulation in adult rat cortical slices. CPPG is a potent antagonist against group II/III mGlu receptors in the adult rat cortex and shows moderate selectivity for group III mGlu receptors. Conversely, CPPG has weak effects at group I mGlu receptors in both the neonatal rat cortex and cultured cerebellar granule cells[1].
| Catalog Number | M033049 |
| CAS Number | 183364-82-1 |
| Synonyms | 2-amino-2-cyclopropyl-2-(4-phosphonophenyl)acetic acid |
| Molecular Formula | C11H14NO5P |
| Purity | ≥95% |
| InChI | InChI=1S/C11H14NO5P/c12-11(10(13)14,7-1-2-7)8-3-5-9(6-4-8)18(15,16)17/h3-7H,1-2,12H2,(H,13,14)(H2,15,16,17) |
| InChIKey | IGODGTDUQSMDQU-UHFFFAOYSA-N |
| SMILES | C1CC1C(C2=CC=C(C=C2)P(=O)(O)O)(C(=O)O)N |
| Reference | [1]. Toms NJ, et al. The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol. 1996 Nov;119(5):851-4. |
