For research use only. Not for therapeutic Use.
CPPZ is a novel positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGlu5).
| Catalog Number | I025170 |
| CAS Number | 945422-18-4 |
| Synonyms | CPPZ; CP PZ; CP-PZ; |
| Molecular Formula | C18H19ClFN3O2 |
| Purity | 98% |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 1-(4-(2-chloro-4-fluorophenyl)piperazin-1-yl)-2-(pyridin-4-ylmethoxy)ethan-1-one |
| InChI | InChI=1S/C18H19ClFN3O2/c19-16-11-15(20)1-2-17(16)22-7-9-23(10-8-22)18(24)13-25-12-14-3-5-21-6-4-14/h1-6,11H,7-10,12-13H2 |
| InChIKey | XNOMHUDLVRWWLV-UHFFFAOYSA-N |
| SMILES | FC1=CC=C(N2CCN(C(COCC3=CC=NC=C3)=O)CC2)C(Cl)=C1 |
| Reference | 1: Spear N, Gadient RA, Wilkins DE, Do M, Smith JS, Zeller KL, Schroeder P, Zhang M, Arora J, Chhajlani V. Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator. Eur J Pharmacol. 2011 Jun 1;659(2-3):146-54. doi: 10.1016/j.ejphar.2011.02.003. Epub 2011 Feb 16. PMID: 21335002. |
