For research use only. Not for therapeutic Use.
CPT-157633, a difluoro-phosphonomethyl phenylalanine derivative, and is a PTP1B inhibitor. CPT-157633 prevents binge drinking-induced glucose intolerance[1].
CPT-157633 (0.2 µg/day; intracerebroventricular infusion) alleviates the hypothalamic inflammation and glucose intolerance induced by binge drinking in rats[1].
| Catalog Number | I045629 |
| CAS Number | 888213-72-7 |
| Synonyms | [[2-bromo-4-[(2S)-2-(methanesulfonamido)-3-(methylamino)-3-oxopropyl]phenyl]-difluoromethyl]phosphonic acid |
| Molecular Formula | C12H16BrF2N2O6PS |
| Purity | ≥95% |
| InChI | InChI=1S/C12H16BrF2N2O6PS/c1-16-11(18)10(17-25(2,22)23)6-7-3-4-8(9(13)5-7)12(14,15)24(19,20)21/h3-5,10,17H,6H2,1-2H3,(H,16,18)(H2,19,20,21)/t10-/m0/s1 |
| InChIKey | GNQQLTLSVIWPPQ-JTQLQIEISA-N |
| SMILES | CNC(=O)C(CC1=CC(=C(C=C1)C(F)(F)P(=O)(O)O)Br)NS(=O)(=O)C |
| Reference | [1]. Lindtner C, et, al. Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action. Sci Transl Med. 2013 Jan 30;5(170):170ra14. |
