For research use only. Not for therapeutic Use.
CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds DOCK2DHR-2 domain and inhibits the guanine nucleotide exchange factor activity of DOCK2DHR-Chemicalbook2 on Rac1 in a dose-dependent manner with IC50 of 22.8 µM. CPYPP also inhibits DOCK180 and DOCK5, and to a lesser extent DOCK9.
| Catalog Number | I010980 |
| CAS Number | 310460-39-0 |
| Synonyms | 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione |
| Molecular Formula | C18H13ClN2O2 |
| Purity | ≥95% |
| Target | DOCK |
| Solubility | Soluble to 50 mM in DMSO |
| Storage | 2-8°C |
| IUPAC Name | (4Z)-4-[(E)-3-(2-chlorophenyl)prop-2-enylidene]-1-phenylpyrazolidine-3,5-dione |
| InChI | InChI=1S/C18H13ClN2O2/c19-16-12-5-4-7-13(16)8-6-11-15-17(22)20-21(18(15)23)14-9-2-1-3-10-14/h1-12H,(H,20,22)/b8-6+,15-11- |
| InChIKey | VVZJFICTTKPNCK-XWDZFIQBSA-N |
| SMILES | C1=CC=C(C=C1)N2C(=O)C(=CC=CC3=CC=CC=C3Cl)C(=O)N2 |
