For research use only. Not for therapeutic Use.
CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines[1].
CQ211 (0-5.0 μM; 4 h) suppresses the phosphorylation of mTOR in cancer cells[1].
CQ211 can obviously suppress the proliferation of MKN-1 and HT-29 cells with IC50 values of 0.61 μM and 0.38 μM, respectively[1].
CQ211 (25 mg/kg; i.p; for 18 consecutive days; once daily) inhibits MKN-1 xenograft mouse model[1].
| Catalog Number | I043655 |
| CAS Number | 2648986-65-4 |
| Synonyms | 8-(6-methoxypyridin-3-yl)-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]-5H-triazolo[4,5-c]quinolin-4-one |
| Molecular Formula | C26H22F3N7O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H22F3N7O2/c1-38-22-7-3-16(14-31-22)15-2-5-20-18(12-15)24-23(25(37)32-20)33-34-36(24)17-4-6-21(19(13-17)26(27,28)29)35-10-8-30-9-11-35/h2-7,12-14,30H,8-11H2,1H3,(H,32,37) |
| InChIKey | RGHLRMNPUGUZEY-UHFFFAOYSA-N |
| SMILES | COC1=NC=C(C=C1)C2=CC3=C(C=C2)NC(=O)C4=C3N(N=N4)C5=CC(=C(C=C5)N6CCNCC6)C(F)(F)F |
| Reference | [1]. Ouyang Y, et al. Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J Med Chem. 2022 Jun 9;65(11):7833-7842. |
