CR-1-31-B (CAT: I015195) is a potent inhibitor of eIF4A RNA helicase, an enzyme involved in the translation initiation process. By targeting eIF4A, CR-1-31-B inhibits the translation of MUC1-C, a protein associated with breast cancer. In breast cancer cells, CR-1-31-B blocks MUC1-C translation in response to growth factor stimulation, leading to a decrease in MUC1-C abundance. This compound has shown efficacy in inhibiting MUC1-C expression in both normal and breast cancer cells. The inhibition of MUC1-C translation by CR-1-31-B represents a potential therapeutic approach for breast cancer treatment. Further research is underway to explore its clinical applications and potential as an anticancer agent.
| Catalog Number | I015195 |
| CAS Number | 1352914-52-3 |
| Molecular Formula | C₂₈H₂₉NO₈ |
| Purity | 95% |
| Reference | [1]. Jin C, Rajabi H, Rodrigo CM, Porco JA Jr, Kufe D. Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein. Oncogene. 2013;32(17):2179-2188. |
